Ctcf zinc fingers
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus … See more The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs … See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease". Trends Genet. 17 (9): 520–7. See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the outcome or if it does so indirectly (in particular through its looping role). Transcriptional … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more WebThe ubiquitously expressed CCCTC-binding factor (CTCF) is a highly conserved transcription factor carrying 11 zinc finger domains involved in multiple DNA sequence-specific recognition [1,2,3].Combinatorial use of zinc fingers is also responsible for CTCF pleiotropic functions including transcriptional activation/repression, insulator activity, and …
Ctcf zinc fingers
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WebWe have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved … WebMar 19, 2024 · transcriptional repressor CTCF Names 11-zinc finger protein CTCFL paralog. NCBI Reference Sequences (RefSeq) Go to the top of the page Help. NEW Try …
WebFeb 16, 2024 · Silencing CTCF or COL1A1/COL1A3 markedly inhibited cell growth and migration in the metastatic GC cell line BGC823. Collectively, this ECM-related 7-gene … WebBACKGROUND: CTCF (CCCTC-binding factor) is an evolutionarily conserved zinc finger protein involved in diverse functions ranging from negative regulation of MYC, to chromatin insulation of the ...
WebCTCF is a ubiquitous 11 zinc finger (ZF) protein with highly versatile functions. A transcriptional repressor, CTCF, binds to promoters of vertebrate c-myc gene. It also binds to the PLK and PIM1 promoters. CTCF may prevent the access of transcriptional activators to enhancers. CTCF also acts as a transcriptional activator of APP. WebCTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact, its DNA binding sites are enriched at the borders of chromatin domains. ... CTCF (CCCTC-binding factor) is an 11-zinc finger protein, which was initially described to bind 3 repeats of ...
WebCTCF is a multivalent transcription factor and uses different combinations of zinc fingers (ZFs) to bind diverse target sequences . Tumor-derived point mutations in ZF3 and ZF7 did not totally abrogate the DNA-binding …
WebBelongs to the CTCF zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Domain. The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost identical amino acid sequences. Different subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA target sites. i miss you my friend lyricsWebJul 29, 2024 · The 11 zinc finger (ZF) protein CTCF regulates topologically associating domain formation and transcription through selective binding to thousands of genomic sites. Here, we replaced endogenous ... i miss you my buddy smokey robinsonWebBelongs to the CTCF zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Domain. The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost … i miss you my friend smokey robinsonWebBelongs to the CTCF zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Domain. The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost identical amino acid sequences. Different subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA target sites. list of red eyes cardsWebOct 27, 2024 · Thus, ZF8 connects CTCF zinc fingers that recognize modules 1-2 and functions as a bridge to span the gap between modules 1 and 2 (Supplementary information, Figure S4). In contrast to ZFs 3-7 and ... i miss you my lovely wifeWebJan 14, 2024 · Furthermore, CTCF–BORIS chimeric constructs provided evidence that, besides the N terminus of CTCF, the first two CTCF zinc fingers, and likely the 3D geometry of CTCF–DNA complexes, are also involved in cohesin retention. Based on this knowledge, we were able to convert BORIS into CTCF with respect to cohesin … i miss you much songWebMay 17, 2024 · We found a central motif that matches the CTCF core motif and an upstream motif at the same location as a previously reported element recognized by CTCF zinc-fingers 9–11 53,54,55 (Fig. 3e). i miss you my little pony