Camptothecin selleck
WebCamptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. Their molecular target has been firmly established to be human DNA topoisomerase I (topo I). CPT inhibits topo I by blocking the rejoining step of the cleavage/religation reaction of topo-I, resulting in accumulation of a covalent ... WebJan 7, 2024 · Camptothecin (CPT), is known to enhance anti-cancer activity with other compounds . Thus, we explored the potential combinatorial apoptotic activity of CPT in …
Camptothecin selleck
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WebCamptothecin, a plant alkaloid orignially isolated from Camptotheca acuminate in 1966. [1] Camptothecin is noted to halt cells during the S phase of mitosis. Camptothecin … WebSynonym(s): Camptothecin, 10-Hydroxy-, Camptotheca acuminata. Empirical Formula (Hill Notation): C 20 H 16 N 2 O 5. CAS No.: 64439-81-2. Molecular Weight: 364.35. Compare Product No. Description SDS …
Webwhen using products from Selleck Chemicals? (1) For oily compounds, add DMSO to dissolve the compound and prepare a stock solution with a concentration according to … WebJan 7, 2024 · Camptothecin has been used in tumor therapy for a long time but its antitumor effect is rather limited due to the side effect and the drug resistance. FEN1, a major component of DNA repair...
WebCamptothecin (CPT), a well-known anticancer agent, could induce apoptosis and autophagy in cancer cells. However, whether CPT could affect the neddylation pathway … WebSAFETY DATA SHEET Creation Date 03-Dec-2010 Revision Date 25-Dec-2024 Revision Number 4 1. Identification Product Name (+)-Camptothecin Cat No. : AC276720000; AC276720010; AC276721000 CAS No 7689-03-4 Synonyms 4-Ethyl-4-hydroxy-1H-pyrano-ó3`,4`:6,7!indolizinoó1,2-b!quinoline-3,14(4H,12H)-dione Recommended Use Laboratory …
WebDec 25, 2024 · Camptothecin (CPT) was purchased from Selleck (Shanghai, China) and dissolved with dimethyl sulfoxide (DMSO, #D8372, Beijing Solarbio Science & Technology Co., Ltd., Beijing, China). 2.5 mL CPT solutions with the concentrations of 400 and 2000 μg/mL were mixed into 1 kg artificial diets, and make the final CPT concentrations as 1.0 …
WebCamptothecin, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more danplan hosuh personalityWebNov 7, 2024 · Camptothecin markedly suppressed NRF2 expression and transcriptional activity in different types of cancer cells including HepG2, SMMC-7721 and A549. As a result, camptothecin sensitised these cells to chemotherapeutic drugs … dan pink\u0027s theory of motivationWebOct 10, 2024 · Chemical agents used were as follows: RO3306 (Selleck), CDK2 inhibitor II (Selleck), Aphidicolin (Sigma), camptothecin (Selleck), Cisplatin (Selleck), and Olaparib (Selleck). Immunofluorescence and fluorescence microscopy. dan pio waste connectionsWebCamptothecin analogues and derivatives appear to exert their antitumour activity by binding to topoisomerase I and have shown significant activity against a broad range of tumours. In general, camptothecins are not substrates for either the multidrug-resistance P-glycoprotein or the multidrug-resistance-associated protein (MRP). dan plante kusi wife meredithWebLipophilicity may represent a better predictor of in vivo efficacy than in vitro IC50 measurements for camptothecins. The identified relationships between efficacy, clearance, and lipohilicity may help guide development of new camptothecin analogs and delivery systems with improved pharmacologic profiles. danplan can you survive horror islandWebOct 1, 2006 · Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme, and is the only known target of the camptothecin and its derivatives. The mechanisms and molecular determinants of the tumour ... danplan hosuh faceWebCamptothecin ( CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine. dan pink three elements of motivation